NHLBI Strategic Visioning: Use isogenic iPS cells to advance Precision Medicine

Dr. Bruce Conklin at the Gladstone Institute of Cardiovascular Disease has posted a "challenge" to the NHLBI Strategic Visioning Initiative titled: "Use isogenic iPS cells to advance Precision Medicine."

JAMA Publication -- Joseph Wu, M.D., Ph.D., Stanford University

Dr. Joseph Wu at Stanford University recently published an article in JAMA:

Wilson KD and Wu JC. Scientific Discovery and the Future of Medicine: Induced Pluripotent Stem Cells. JAMA 2015; 313(16):1613-1614. doi:10.1001/jama.2015.1846.

Please visit http://jama.jamanetwork.com/article.aspx?articleid=2279720 for more information.

In the coming decades, data gained from iPSCs could constitute one of the most promising primary building blocks of precision medicine.

Nature Cell Biology Publication -- Gordon Keller, Ph.D., University Health Network

Dr. Gordon Keller at the University Health Network recently published an article in Nature Cell Biology:

Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol. 2015 Apr 27. doi: 10.1038/ncb3161. [Epub ahead of print]

This paper is likely to have significant implications for the derivation of haematopoietic stem cells from hiPSCs.

Cardiovascular Tissue Engineering Symposium - May 22, 2015

Dr. Joseph Wu and colleagues cordially invite you to attend the upcoming Cardiovascular Tissue Engineering Symposium at Stanford. This event, sponsored by the Stanford Cardiovascular Institute, features a number of PCBC investigators and is free of charge to all PCBC members. Please save the date (Friday, May 22nd, 2015) and register at the following website link http://tinyurl.com/cvte2015.

More details:

NIH Genomic Data Sharing (GDS) Policy

To promote sharing of human and non-human genomic data and to provide appropriate protections for research involving human data, the National Institutes of Health (NIH) issued the Genomic Data Sharing (GDS) Policy on August 27, 2014, in the NIH Guide Grants and Contracts (available at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-124.html). The GDS Policy is also available at http://gds.nih.gov/03policy2.html.

A microRNA-Hippo Pathway that Promotes Cardiomyocyte Proliferation and Cardiac Regeneration in Mice

A team led by Ed Morrisey, PhD, a professor of Medicine and Cell and Developmental Biology and the scientific director of the Institute for Regenerative Medicine in the Perelman School of Medicine at the University of Pennsylvania, has now shown that a subset of RNA molecules, called microRNAs, is important for cardiomyocyte cell proliferation during development and is sufficient to induce proliferation in cardiomyocytes in the adult heart.

NIH Funding Opportunity Announcements

NIH Big Data to Knowledge (BD2K) Enhancing Diversity in Biomedical Data Science (R25)

FOA #: RFA-MD-15-005

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

PCBC Investigator Helen Blau, professor of microbiology and immunology at Stanford University and director of the university's Baxter Laboratory for Stem Cell Biology, and colleagues have published an important discovery toward lengthening telomeres in The Federation of American Societies for Experimental Biology (FASEB) Journal (http://www.fasebj.org).

Tenascin C Promotes Hematoendothelial Development and T Lymphoid Commitment from hPSCs in Chemically Defined Conditions

Gene Uenishi, a graduate student, in Dr. Igor Slukvin’s laboratory under the Thomson Hub Site 02 at the University of Wisconsin – Madison, has recently published an article titled, “Tenascin C Promotes Hematoendothelial Development and T Lymphoid Commitment from Human Pluripotent Stem Cells in Chemically Defined Conditions” in the Stem Cell Reports.

Protocols and Reagents

Platform for Sharing and Accessing Available Protocols and Reagents

The PCBC Synapse platform, in addition to storing data is a resource for the aggregation and dissemination of protocols and reagents for the consortium.

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